2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

Related Products

PDF 38.29 MB

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140260
    NH-bis(PEG3-C2-NH-Boc) 2055024-51-4
    NH-bis(PEG3-C2-NH-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH-bis(PEG3-C2-NH-Boc)
  • HY-141401
    m-PEG13-Boc
    m-PEG13-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG13-Boc
  • HY-140186
    Amino-PEG36-acid 2241751-76-6
    Amino-PEG36-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG36-acid
  • HY-134693
    Azido-C1-PEG4-C3-NH2
    Azido-C1-PEG4-C3-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-C1-PEG4-C3-NH2 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-C1-PEG4-C3-NH2
  • HY-140622
    Ald-Ph-amido-PEG24-acid
    Ald-Ph-amido-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Ald-Ph-amido-PEG24-acid
  • HY-132107
    MS-PEG3-THP 357204-84-3
    MS-PEG3-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    MS-PEG3-THP
  • HY-140562
    N-(Azido-PEG2)-N-Boc-PEG3-Boc 2093153-07-0
    N-(Azido-PEG2)-N-Boc-PEG3-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG2)-N-Boc-PEG3-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Azido-PEG2)-N-Boc-PEG3-Boc
  • HY-140444
    Cbz-aminooxy-PEG8-Boc
    Cbz-aminooxy-PEG8-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Cbz-aminooxy-PEG8-Boc
  • HY-133315
    HO-PEG1-benzyl ester 2752298-46-5
    HO-PEG1-benzyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    HO-PEG1-benzyl ester
  • HY-140607
    m-PEG3-Sulfone-PEG3 1919045-00-3
    m-PEG3-Sulfone-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG3-Sulfone-PEG3
  • HY-140554
    N-Boc-N-bis(C2-PEG1-azide) 2100306-79-2
    N-Boc-N-bis(C2-PEG1-azide) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. N-Boc-N-bis(C2-PEG1-azide) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-Boc-N-bis(C2-PEG1-azide)
  • HY-138765
    Propargyl-PEG7-amine
    Propargyl-PEG7-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG7-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG7-amine
  • HY-141102
    Fmoc-PEG24-NHS ester
    Fmoc-PEG24-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-PEG24-NHS ester
  • HY-116025
    APN-C3-PEG4-alkyne 2183440-36-8
    APN-C3-PEG4-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. APN-C3-PEG4-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    APN-C3-PEG4-alkyne
  • HY-140475
    Boc-NH-PEG36-CH2CH2COOH
    Boc-NH-PEG36-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG36-CH2CH2COOH
  • HY-138530
    Thiol-PEG4-amide-NH2
    Thiol-PEG4-amide-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Thiol-PEG4-amide-NH2
  • HY-130909
    Propargyl-PEG25-acid
    Propargyl-PEG25-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG25-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG25-acid
  • HY-159572
    NH2-C5-Azacyclohexane-N-Boc
    NH2-C5-Azacyclohexane-N-Boc is a PROTAC linker. NH2-C5-Azacyclohexane-N-Boc can be used in synthesis XD2-149 (HY-159570).
    NH2-C5-Azacyclohexane-N-Boc
  • HY-122413
    m-PEG7-NHS ester 874208-92-1
    m-PEG7-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG7-NHS ester
  • HY-141201
    m-PEG3-aminooxy-Boc 1835759-87-9
    m-PEG3-aminooxy-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG3-aminooxy-Boc
PROTAC Linkers Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.